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I’m Gaëlle Houthaeve and for the past 5 years I have been doing an interdisciplinary PhD with Prof. Winnok De Vos in the Laboratory of Cell Biology and Histology and Prof. Kevin Braeckmans. My PhD research has focused on vapor nanobubble photoporation, which uses laser light (“photo”) to generate vapor nanobubbles, which are able to porate the plasma membrane of cells (“poration”).

During her PhD research in Biomedical Sciences, Emilie Logie aimed to find new treatment options to overcome therapy resistance in the blood cancer multiple myeloma. Together with Professor Wim Vanden Berghe, her supervisor at the Proteinchemistry, Proteomics and Epigenetic Signalling (PPES) lab, Emilie used and combined different molecular techniques to identify new ways for treating therapy-resistant multiple myeloma cancers.

Bahaa Shaqour is a PhD student from Palestine and he is working with Prof. Paul Cos at the Laboratory for Microbiology, Parasitology and Hygiene (LMPH). He is exploring the capabilities of 3D printing technologies to produce novel medication delivery systems. 3D printing, also known as additive manufacturing, is a method of creating a three dimensional object layer-by-layer using a computer generated design.

New research findings by Prof. Vincent Timmerman’s group has revealed common hallmarks in motor neurons of patients with different subtypes of Charcot-Marie-Tooth disease (CMT) type 2, including impaired axonal transport and mitochondrial dysfunction. Targeting these underlying disease mechanisms could pave the way for treatments that can help a larger group of CMT patients.

New research from Prof. Vincent Timmerman’s lab, in collaboration with researchers from the University of Oxford, has elucidated the structural changes caused by a mutation in the molecular chaperone Hsp27 (HSPB1). Chaperones are a group of proteins that have functional similarity and assist in protein folding. This work not only sheds light on an important disease-causing mutation, it also reveals an important mechanism by which this chaperone functions.

Researchers from the Laboratory for Microbiology, Parasitology and Hygiene (LMPH) and the Toxicological Centre, have joined forces with the Belgian health agency Sciensano to measure levels of the Coronavirus (SARS-CoV-2) in wastewater. This research builds on methodologies and expertise that were previously optimized by Prof. Peter Delputte and Prof. Alexander van Nuijs.

Despite decades of research and recent advances based on genetics and brain imaging, the exact mechanisms underlying Attention Deficit Hyperactivity Disorder (ADHD) and a viable and effective treatment are still undiscovered. Dr. Annelies Verlaet, a researcher in the NatuRA group is investigating the use of plant extracts for the treatment of ADHD.

Leishmaniasis is a neglected tropical parasitic disease caused by Leishmania species that are transmitted by the bites of female sand flies. The failure rate of leishmaniasis treatment is rising in recent years due to the emergence of resistance to the major antileishmanial drugs. Evaluating the impact of drug resistance on parasite fitness is pivotal for monitoring its development and spread.