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25/01/2023 | By Bronwen Martin

Small heat shock proteins play an important role in keeping mitochondria healthy

In a recent study published in the journal Nature Cell Biology, Dr. Elias Adriaenssens, Prof. Vincent Timmerman and colleagues have discovered a new function for a group of proteins called small heat shock proteins (HSPBs) in the human body. These proteins, which are found in the liquid (cytosolic) portion of cells, were found to play a critical role in the maintenance of the powerhouses of cells, the mitochondria.

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03/03/2021 | By Bronwen Martin

Important changes in the protein structure of a mutated chaperone cause Charcot-Marie-Tooth disease

New research from Prof. Vincent Timmerman’s lab, in collaboration with researchers from the University of Oxford, has elucidated the structural changes caused by a mutation in the molecular chaperone Hsp27 (HSPB1). Chaperones are a group of proteins that have functional similarity and assist in protein folding. This work not only sheds light on an important disease-causing mutation, it also reveals an important mechanism by which this chaperone functions.

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