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This year’s Nobel Prize in Chemistry is awarded to David Baker (University of Washington, Seattle, USA), Demis Hassabis, and John Jumper (Google DeepMind, UK) for their work on developing Rosetta (Baker) and AlphaFold (Hassabis and Jumper). These open-source software tools enable researchers worldwide to go from an amino acid sequence to a 3D structure of a protein with just one mouse click.