{"id":3046,"date":"2024-11-28T14:28:15","date_gmt":"2024-11-28T14:28:15","guid":{"rendered":"https:\/\/blog.uantwerpen.be\/fbd\/?p=3046"},"modified":"2024-11-29T10:54:20","modified_gmt":"2024-11-29T10:54:20","slug":"exploring-thalassia-a-seagrass-with-anti-cancer-potential","status":"publish","type":"post","link":"https:\/\/blog.uantwerpen.be\/fbd\/exploring-thalassia-a-seagrass-with-anti-cancer-potential\/","title":{"rendered":"Exploring Thalassia: A Seagrass with Anti-Cancer Potential"},"content":{"rendered":"\n<p><strong>Seas and oceans harbor countless undiscovered treasures. One of these is the seagrass <em>Thalassia<\/em>, specifically the species <em>Thalassia testudinum<\/em>. Long recognized for its ecological importance, this marine plant serves as a vital food source for creatures like sea turtles and plays a key role in protecting vulnerable Caribbean coastal ecosystems. Recently, scientists have discovered that <em>Thalassia<\/em> contains significant anti-carcinogenic compounds, capturing the attention of researchers and marine science biomedical institutes. Currently, the plants are harvested from their natural habitats for laboratory processing. However, this practice could cause tremendous pressure on the species, leading to biodiversity loss and potential ecological disasters.<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-large is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"683\" height=\"1024\" src=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/2374-2-683x1024.jpg\" alt=\"\" class=\"wp-image-3087\" style=\"width:301px;height:auto\" srcset=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/2374-2-683x1024.jpg 683w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/2374-2-200x300.jpg 200w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/2374-2-768x1152.jpg 768w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/2374-2-1024x1536.jpg 1024w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/2374-2-1365x2048.jpg 1365w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/2374-2-scaled.jpg 1707w\" sizes=\"(max-width: 683px) 100vw, 683px\" \/><\/figure>\n<\/div>\n\n\n<p>Professor Wim Vanden Berghe\u2019s lab in <a href=\"https:\/\/www.uantwerpen.be\/en\/research-groups\/proteinchemistry-proteomics-epigenet\/\" target=\"_blank\" rel=\"noopener\" title=\"Cell Death Signaling\">Cell Death Signaling<\/a>, in collaboration with <a href=\"https:\/\/www.linkedin.com\/in\/emmy-tuenter\/\" target=\"_blank\" rel=\"noopener\" title=\"Prof. Emmy Tuenter\">Prof. Emmy Tuenter<\/a>\u2019s <a href=\"https:\/\/www.uantwerpen.be\/en\/research-groups\/naturapt\/\" target=\"_blank\" rel=\"noopener\" title=\"pharmacognosy lab\">pharmacognosy lab<\/a>, UGent colleagues of <a href=\"https:\/\/www.invitro-ugent.be\/\" target=\"_blank\" rel=\"noopener\" title=\"Plant\">Plant<\/a>\u00a0and <a href=\"https:\/\/bluegent.ugent.be\/\" target=\"_blank\" rel=\"noopener\" title=\"Blue biotechnology\">Blue biotechnology<\/a>, together with partners at the <a href=\"https:\/\/www.innovoceancampus.be\/en\/\" target=\"_blank\" rel=\"noopener\" title=\"VLIZ-Innovocean\">VLIZ-Innovocean<\/a> campus in Ostend, University of Havana and the <a href=\"https:\/\/www.facebook.com\/icimar.cuba\/\" target=\"_blank\" rel=\"noopener\" title=\"ICIMAR Institute of Marine Research\">ICIMAR Institute of Marine Research<\/a> in Cuba, are investigating sustainable ways of <em>in vitro<\/em> cultivation of these plants, enabling the extraction of the seagrass\u2019 anti-cancer compounds without harming the environment.<\/p>\n\n\n\n<p><strong>In Vitro Cultivation<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-1-1024x768.jpg\" alt=\"\" class=\"wp-image-3095\" style=\"width:335px;height:auto\" srcset=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-1-1024x768.jpg 1024w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-1-300x225.jpg 300w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-1-768x576.jpg 768w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-1-1536x1152.jpg 1536w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-1-2048x1536.jpg 2048w\" sizes=\"(max-width: 706px) 89vw, (max-width: 767px) 82vw, 740px\" \/><\/figure>\n<\/div>\n\n\n<p>\u2018With this North-South VLIR-UOS supported TEAM project, the international research consortium focuses on isolating bioactive compounds from <em>Thalassia<\/em> that function as new anti-cancer agents\u2019, explains Professor Wim Vanden Berghe of the University of Antwerp. For Cuban partners, <em>Thalassia<\/em> initially posed a logistical issue: large amounts of the seagrass wash ashore annually, rot, and starts smelling, deterring tourists. \u2018Instead of destroying it all, our colleagues investigated whether the plants contained any recyclable medicinal bioactive compounds. They managed to isolate and identify a new biomedical component\u2019, says Vanden Berghe.<\/p>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"768\" data-id=\"3060\" src=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-11-1024x768.jpg\" alt=\"\" class=\"wp-image-3060\" srcset=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-11-1024x768.jpg 1024w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-11-300x225.jpg 300w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-11-768x576.jpg 768w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-11.jpg 1392w\" sizes=\"(max-width: 706px) 89vw, (max-width: 767px) 82vw, 740px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" data-id=\"3061\" src=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-2-1024x768.jpg\" alt=\"\" class=\"wp-image-3061\" srcset=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-2-1024x768.jpg 1024w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-2-300x225.jpg 300w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-2-768x576.jpg 768w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-2-1536x1152.jpg 1536w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-2-2048x1536.jpg 2048w\" sizes=\"(max-width: 706px) 89vw, (max-width: 767px) 82vw, 740px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" data-id=\"3062\" src=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-4-1024x768.jpg\" alt=\"\" class=\"wp-image-3062\" srcset=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-4-1024x768.jpg 1024w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-4-300x225.jpg 300w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-4-768x576.jpg 768w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-4-1536x1152.jpg 1536w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-4-2048x1536.jpg 2048w\" sizes=\"(max-width: 706px) 89vw, (max-width: 767px) 82vw, 740px\" \/><\/figure>\n<\/figure>\n\n\n\n<p>Currently, the plants are harvested in their natural environment and further processed in laboratories. While this offers potential for cancer treatment, large-scale harvesting risks biodiversity loss and ecological crises.<\/p>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\"><figure class=\"wp-block-media-text__media\"><video controls src=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/In-vitro2.mp4\"><\/video><\/figure><div class=\"wp-block-media-text__content\">\n<p>To address these challenges, Vanden Berghe, his UGent and Cuban collaborators and VLIZ-researchers in Ostend are developing innovative in vitro cultivation techniques for <em>Thalassia<\/em>, ensuring the sustainable extraction of its anti-cancer compounds.<\/p>\n<\/div><\/div>\n\n\n\n<p><br>Beyond its scientific significance, the project has economic implications for Cuba. Medicines are often too expensive with limited availability, while climate change increases sun exposure and the prevalence of skin cancer. Locally producing a treatment provides an affordable and accessible solution.<\/p>\n\n\n\n<div class=\"wp-block-media-text has-media-on-the-right is-stacked-on-mobile\" style=\"grid-template-columns:auto 71%\"><div class=\"wp-block-media-text__content\">\n<p><em>Thalassia is a vital food source for creatures like sea turtles and plays a key role in protecting vulnerable Caribbean coastal ecosystems.<\/em><\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><video controls src=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-onder-water.mp4\"><\/video><\/figure><\/div>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>A Sustainable Future for Marine Medicine<\/strong><\/p>\n\n\n\n<p>Professor Vanden Berghe emphasizes the importance of a sustainable approach complying with the <a href=\"https:\/\/www.cbd.int\/ABS\" target=\"_blank\" rel=\"noopener\" title=\"Nagoya protocol of benefit sharing\">Nagoya protocol of benefit sharing<\/a>: \u2018If the pharmaceutical industry begins harvesting seagrass on a large scale, it will inevitably strain the ecosystem and exhaust local biological and socioeconomic resources.\u2019 The project, therefore, focuses on building local capacity for in vitro cultivation methods, eliminating the need for wild harvesting.<\/p>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile\" style=\"grid-template-columns:26% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"683\" height=\"1024\" src=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/ER-683x1024.jpg\" alt=\"\" class=\"wp-image-3072 size-full\" srcset=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/ER-683x1024.jpg 683w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/ER-200x300.jpg 200w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/ER-768x1152.jpg 768w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/ER-1024x1536.jpg 1024w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/ER-1365x2048.jpg 1365w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/ER-scaled.jpg 1706w\" sizes=\"(max-width: 683px) 100vw, 683px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p>Cuban Ph.D. researcher <a href=\"https:\/\/www.linkedin.com\/in\/elizabeth-reyes-bb48a369\/?originalSubdomain=cu\" target=\"_blank\" rel=\"noopener\" title=\"Elisabeth Reyes\">Elisabeth Reyes<\/a> sees great promise in this approach. \u2018The future of marine phytomedicine is bright. We\u2019re achieving excellent results with our in vitro models. This is not only crucial for our project but also for the broader development of natural medicines. It\u2019s more affordable than expensive antibodies and more accessible for our society.\u2019<\/p>\n\n\n\n<p>The team plans to present their findings to the regulatory authorities soon and begin (pre)clinical trials. \u2018If in vitro production succeeds, it\u2019s a win-win\u2019, Reyes concludes.<\/p>\n<\/div><\/div>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-default is-cropped wp-block-gallery-2 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" data-id=\"3078\" src=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/IMG_2531-1024x768.jpg\" alt=\"\" class=\"wp-image-3078\" srcset=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/IMG_2531-1024x768.jpg 1024w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/IMG_2531-300x225.jpg 300w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/IMG_2531-768x576.jpg 768w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/IMG_2531.jpg 1225w\" sizes=\"(max-width: 706px) 89vw, (max-width: 767px) 82vw, 740px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" data-id=\"3077\" src=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/438781718_975474587917558_8701604445685115986_n-1-1024x768.jpeg\" alt=\"\" class=\"wp-image-3077\" srcset=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/438781718_975474587917558_8701604445685115986_n-1-1024x768.jpeg 1024w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/438781718_975474587917558_8701604445685115986_n-1-300x225.jpeg 300w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/438781718_975474587917558_8701604445685115986_n-1-768x576.jpeg 768w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/438781718_975474587917558_8701604445685115986_n-1.jpeg 1392w\" sizes=\"(max-width: 706px) 89vw, (max-width: 767px) 82vw, 740px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" data-id=\"3093\" src=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-8-1024x768.jpg\" alt=\"\" class=\"wp-image-3093\" srcset=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-8-1024x768.jpg 1024w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-8-300x225.jpg 300w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-8-768x576.jpg 768w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-8-1536x1152.jpg 1536w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-8-2048x1536.jpg 2048w\" sizes=\"(max-width: 706px) 89vw, (max-width: 767px) 82vw, 740px\" \/><\/figure>\n<\/figure>\n\n\n\n<p>This project could set a precedent for the future of natural plant medicines, demonstrating how a marine seagrass derived compound can lead to cost-effective treatments for cancer patients. The research into <em>Thalassia testudinum<\/em> highlights how science, sustainability, and innovation can go hand in hand demonstrating how the VLIR-UOS philosophy of \u201csharing minds can change lives\u201d.<\/p>\n\n\n\n<div class=\"wp-block-media-text is-stacked-on-mobile has-pale-cyan-blue-background-color has-background\" style=\"grid-template-columns:32% auto\"><figure class=\"wp-block-media-text__media\"><img loading=\"lazy\" decoding=\"async\" width=\"651\" height=\"1024\" src=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-PNG-2-651x1024.png\" alt=\"\" class=\"wp-image-3050 size-full\" srcset=\"https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-PNG-2-651x1024.png 651w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-PNG-2-191x300.png 191w, https:\/\/blog.uantwerpen.be\/fbd\/wp-content\/uploads\/2024\/11\/Thalassia-PNG-2.png 692w\" sizes=\"(max-width: 651px) 100vw, 651px\" \/><\/figure><div class=\"wp-block-media-text__content\">\n<p><strong>The Ocean as the Pharmacy of the Future<\/strong><\/p>\n\n\n\n<p>Plants possess primitive defense mechanisms, being in an early stage of evolution and lacking an immune system like ours. Instead of white blood cells, they rely on oxidative iron metabolic responses for defense. This ancient mechanism is also found in marine organisms such as seaweeds and algae, which lack immune systems and manipulate oxidative rusting systems to survive\u2014a process called ferroptosis.<\/p>\n\n\n\n<p>Ferroptosis is a specific type of programmed cell death where a cell dies because its membrane is attacked by oxidative rust and disintegrates. Since certain cancer cells are particularly vulnerable to this, ferroptosis offers an intriguing strategy for killing them. By activating processes that enhance ferroptosis, scientists may better combat tumors and inhibit their growth.<\/p>\n<\/div><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Seas and oceans harbor countless undiscovered treasures. One of these is the seagrass Thalassia, specifically the species Thalassia testudinum. Long recognized for its ecological importance, this marine plant serves as a vital food source for creatures like sea turtles and plays a key role in protecting vulnerable Caribbean coastal ecosystems. Recently, scientists have discovered that Thalassia contains significant anti-carcinogenic compounds, capturing the attention of researchers and marine science biomedical institutes.<\/p>\n","protected":false},"author":10,"featured_media":3059,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[5,56,30],"tags":[97,157,244,74,65,254,253],"class_list":["post-3046","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-research","category-environmental-health","category-research","tag-biomedicalsciences","tag-ferroptosis","tag-pharmaceutical-sciences","tag-phd","tag-research","tag-seagrass","tag-thalassia"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/blog.uantwerpen.be\/fbd\/wp-json\/wp\/v2\/posts\/3046","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.uantwerpen.be\/fbd\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.uantwerpen.be\/fbd\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.uantwerpen.be\/fbd\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.uantwerpen.be\/fbd\/wp-json\/wp\/v2\/comments?post=3046"}],"version-history":[{"count":5,"href":"https:\/\/blog.uantwerpen.be\/fbd\/wp-json\/wp\/v2\/posts\/3046\/revisions"}],"predecessor-version":[{"id":3103,"href":"https:\/\/blog.uantwerpen.be\/fbd\/wp-json\/wp\/v2\/posts\/3046\/revisions\/3103"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.uantwerpen.be\/fbd\/wp-json\/wp\/v2\/media\/3059"}],"wp:attachment":[{"href":"https:\/\/blog.uantwerpen.be\/fbd\/wp-json\/wp\/v2\/media?parent=3046"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.uantwerpen.be\/fbd\/wp-json\/wp\/v2\/categories?post=3046"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.uantwerpen.be\/fbd\/wp-json\/wp\/v2\/tags?post=3046"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}